Capto L combines a rigid, high-flow agarose matrix with the immunoglobulin-binding recombinant protein L ligand, which has a strong affinity to the variable region of antibody kappa light chains. As a result, you can save considerable manufacturing costs in your mAb production. Affinity resin for antibody fragment purification. This represented a HCPs reduction above 160-fold for the Capto MMC resin, and 30-fold for the. Host cell proteins were reduced efficiently to 4048 ng/mg antibody (4048 ppm) for the Capto MMC resin and 193250 ng/mg antibody for the Capto S resin. proteins and post-protein A steps for mAbs.īased on a 85µm diameter base bead, Eshmuno® S exhibits a superior binding capacity combined with an excellent pressure flow behavior, resulting in outstanding productivity of more than 40 mg/ml per hour in downstream processing. In the case of Capto S resin, yield and purity were acceptable but significantly lower. Highly productive in direct capture of rec.This combination allows the use of much higher flow rates while the biomolecule is still strongly bound by the tentacle. Like all other Eshmuno® IEX family members, Eshmuno® S resin combines a tentacle structure for more effective binding of the target molecules with the advantages of an innovative hydrophilic polyvinyl ether base matrix. With Eshmuno® S, you achieve superior productivity and maximum performance in your downstream purification of monoclonal antibodies. Eshmuno® S has a superior binding capacity compared to other modern cation-exchangers. proteins and post-protein A steps for mAbs. It is very important to know what is the Tg (Glass Transition Temperature) or HDT (Heat Distortion Temperature) of the resin in order to know what will be the heat resistance of the part.Request Information The Strong Cation Exchangerįor Downstream mAb Purification Eshmuno® S is a strong cation exchange resin, designed for fast, efficient purification in direct capture of rec. 6 pH range where ligand is fully charged. Free shipping on many items Browse your favorite brands affordable prices. The pressure includes pressure drop from the bed and the column. Get the best deals on 1 700 resin when you shop the largest online selection at. Running conditions: AxiChrom 1000 for Capto S, Chromaflow 1000 for Q Sepharose Fast Flow, 20 cm packed bed, with water at 20C. The cross-linked ag arose matrix provides particle rigidity without compromising the pore size. Capto Butyl HIC resin combines high capacity, high flow rate, and low. The ligands, Q, S and DEAE, are coupled to a highly cross-linked agarose matrix. 5 pH range where resin can be subjected to cleaning- or sanitization-in-place without significant change in function. Pressure/flow curve for Capto S compared to Q Sepharose Fast Flow. Resin properties Capto Q, Capto S and Capto DEAE are high capacity, strong anion, strong cation and weak anion exchangers, respectively. The resin also determines the thermal limit of the composite part. 4 pH range where resin can be operated without significant change in function. Resin also helps to transfer mechanical loads from the fibers of reinforcement to the entire composite part. The matrix bonds the fibres of reinforcement together and helps it conform to a desired shape. So what role does resin play? It serves two basic purposes: Once cured, these finished parts are primarily fiber dominant, meaning their physical properties most resemble those of the reinforcement used. This reaction can also be boosted by UV or IR radiations or just by a source of heat.Ĭomposite laminates are a combination of fibre reinforcement and resin. Thermosetting resins are polymers that react thanks to the addition of a catalyst or a hardener causing an exotherm reaction. We offer resins for hand lay-up, spray-up, infusion, RTM, RTM light, pultrusion, etc. Castro Composites focuses on most of the important thermosetting resins for composite applications.
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